Boost your NEET score with these 50+ high-yield biomolecules chemistry NEET questions. Includes past year’s tricky questions & expert-selected problems. Are you ready? Start practicing now!
Introduction: Importance of Biomolecules in NEET
Biomolecules form the foundation of life sciences and chemistry, making them a highly important topic for NEET. Every year, 4-5 direct questions appear from this topic in NEET Chemistry and Biology. These questions test a student’s understanding of carbohydrates, proteins, lipids, nucleic acids, and enzymes, which are essential for biological functions.
NEET Biomolecules Question Trends (2020-2022)
Analyzing past year papers, we can see a clear pattern in the type of biomolecules questions asked in NEET:
- NEET 2020 Biomolecules Questions – Focused on enzymes and nucleic acids. Questions included enzyme inhibition and DNA structure.
- NEET 2021 Biomolecules Questions – Covered protein structure and carbohydrates. One tricky question was on the classification of amino acids.
- NEET 2022 Biomolecules Questions – Featured lipids and vitamins. A commonly misanswered question involved fatty acid metabolism.
If you’re preparing for NEET 2025, it’s also crucial to stay updated on the NEET 2025 Important Dates so you can plan your studies effectively and stay ahead.
Why is this topic important?
Many biomolecule-based questions require direct NCERT knowledge, while others test your ability to apply concepts in problem-solving. Since NEET repeats concepts, mastering biomolecules increases your chances of scoring high.
Also, before diving into rigorous preparation, be sure to check out the NEET 2025 Qualifying Codes to understand the eligibility requirements—it’s better to be well-prepared in every aspect!
Easy Biomolecules NEET Questions (10-15 Questions)
- Which of the following is a reducing sugar?
- (a) Sucrose
- (b) Maltose
- (c) Starch
- (d) Cellulose
- Answer: (b) Maltose
- The monomer of proteins is:
- (a) Nucleotides
- (b) Fatty Acids
- (c) Amino Acids
- (d) Monosaccharides
- Answer: (c) Amino Acids
- The sugar present in RNA is:
- (a) Glucose
- (b) Deoxyribose
- (c) Ribose
- (d) Fructose
- Answer: (c) Ribose
- An example of a secondary structure of a protein is:
- (a) α-helix
- (b) β-pleated sheet
- (c) Both (a) and (b)
- (d) None
- Answer: (c) Both (a) and (b)
- The nitrogenous bases present in DNA are:
- (a) Adenine, Guanine, Cytosine, Thymine
- (b) Adenine, Guanine, Cytosine, Uracil
- (c) Only Adenine and Guanine
- (d) Only Cytosine and Thymine
- Answer: (a) Adenine, Guanine, Cytosine, Thymine
- e bond between sugar and phosphate in DNA is:
- (a) Hydrogen bond
- (b) Glycosidic bond
- (c) Phosphodiester bond
- (d) Peptide bond
- Answer: (c) Phosphodiester bond
- The enzyme that catalyzes the breakdown of starch into maltose is:
- (a) Pepsin
- (b) Amylase
- (c) Lipase
- (d) Trypsin
- Answer: (b) Amylase
- Proteins are formed by the polymerization of:
- (a) Monosaccharides
- (b) Amino Acids
- (c) Fatty Acids
- (d) Nucleotides
- Answer: (b) Amino Acids
- The number of chiral carbons in glucose is:
- (a) 2
- (b) 4
- (c) 6
- (d) 3
- Answer: (b) 4
- Which of the following is NOT a component of RNA?
- (a) Adenine
- (b) Thymine
- (c) Uracil
- (d) Ribose
- Answer: (b) Thymine
If you’re focusing on NEET Biology, another high-weightage topic you should prioritize is Animal Kingdom NEET Questions. Questions from this section often appear alongside biomolecules in the Biology segment.
Moderate Biomolecules NEET Questions (20-25 Questions)
Here are 25 moderate-level biomolecules questions that align with NEET’s pattern, including previous year questions (PYQs), conceptual questions, and application-based MCQs.
1-5: Questions on Carbohydrates
- Which of the following is a polysaccharide?
- (a) Fructose
- (b) Sucrose
- (c) Starch
- (d) Glucose
- Answer: (c) Starch
- Which of the following carbohydrates is a structural component of plant cell walls?
- (a) Glycogen
- (b) Starch
- (c) Cellulose
- (d) Maltose
- Answer: (c) Cellulose
- Which carbohydrate is stored in the human liver and muscles?
- (a) Starch
- (b) Glycogen
- (c) Cellulose
- (d) Sucrose
- Answer: (b) Glycogen
- The bond that links monosaccharides in a disaccharide is called:
- (a) Peptide bond
- (b) Glycosidic bond
- (c) Phosphodiester bond
- (d) Hydrogen bond
- Answer: (b) Glycosidic bond
- Lactose is composed of which two monosaccharides?
- (a) Glucose and Galactose
- (b) Glucose and Fructose
- (c) Glucose and Glucose
- (d) Fructose and Galactose
- Answer: (a) Glucose and Galactose
6-10: Questions on Proteins and Amino Acids
- The monomers of proteins are:
- (a) Fatty acids
- (b) Nucleotides
- (c) Amino acids
- (d) Monosaccharides
- Answer: (c) Amino acids
- The bond responsible for protein structure is:
- (a) Glycosidic bond
- (b) Phosphodiester bond
- (c) Peptide bond
- (d) Ionic bond
- Answer: (c) Peptide bond
- Which amino acid contains sulfur?
- (a) Glycine
- (b) Cysteine
- (c) Alanine
- (d) Proline
- Answer: (b) Cysteine
- Which protein is responsible for oxygen transport in the blood?
- (a) Myoglobin
- (b) Collagen
- (c) Hemoglobin
- (d) Keratin
- Answer: (c) Hemoglobin
- Enzymes are chemically:
- (a) Proteins
- (b) Carbohydrates
- (c) Lipids
- (d) Nucleic acids
- Answer: (a) Proteins
11-15: Questions on Lipids and Nucleic Acids
- The most abundant lipid in the plasma membrane is:
- (a) Cholesterol
- (b) Phospholipids
- (c) Triglycerides
- (d) Steroids
- Answer: (b) Phospholipids
- Which of the following is a saturated fatty acid?
- (a) Oleic acid
- (b) Linoleic acid
- (c) Palmitic acid
- (d) Arachidonic acid
- Answer: (c) Palmitic acid
- DNA and RNA differ in:
- (a) The number of strands
- (b) The sugar component
- (c) The nitrogenous bases
- (d) All of the above
- Answer: (d) All of the above
- The sugar present in RNA is:
- (a) Ribose
- (b) Deoxyribose
- (c) Fructose
- (d) Glucose
- Answer: (a) Ribose
- The complementary base pair of adenine in DNA is:
- (a) Guanine
- (b) Uracil
- (c) Thymine
- (d) Cytosine
- Answer: (c) Thymine
16-20: Questions on Enzymes and Metabolism
- The enzyme that catalyzes the breakdown of starch into maltose is:
- (a) Pepsin
- (b) Amylase
- (c) Lipase
- (d) Trypsin
- Answer: (b) Amylase
- The enzyme that catalyzes DNA replication is:
- (a) RNA polymerase
- (b) DNA polymerase
- (c) Ligase
- (d) Helicase
- Answer: (b) DNA polymerase
- The site of enzyme where substrate binds is called:
- (a) Active site
- (b) Inhibitor site
- (c) Allosteric site
- (d) Receptor site
- Answer: (a) Active site
- The inhibitor that competes with the substrate for enzyme binding is called:
- (a) Competitive inhibitor
- (b) Non-competitive inhibitor
- (c) Uncompetitive inhibitor
- (d) Allosteric inhibitor
- Answer: (a) Competitive inhibitor
- The final product of glycolysis is:
- (a) Pyruvate
- (b) Glucose
- (c) Acetyl-CoA
- (d) ATP
- Answer: (a) Pyruvate
21-25: Miscellaneous Questions on Biomolecules
- The nitrogenous base that is unique to RNA is:
- (a) Adenine
- (b) Thymine
- (c) Uracil
- (d) Guanine
- Answer: (c) Uracil
- The energy currency of the cell is:
- (a) DNA
- (b) ATP
- (c) RNA
- (d) NADH
- Answer: (b) ATP
- Which vitamin is required for blood clotting?
- (a) Vitamin A
- (b) Vitamin K
- (c) Vitamin C
- (d) Vitamin D
- Answer: (b) Vitamin K
- The enzyme that breaks down fats is:
- (a) Protease
- (b) Lipase
- (c) Amylase
- (d) Helicase
- Answer: (b) Lipase
- Which of the following is a non-reducing sugar?
- (a) Glucose
- (b) Maltose
- (c) Sucrose
- (d) Lactose
- Answer: (c) Sucrose
While solving these, time management is key. If you’re wondering how much time you’ll get per question in NEET, reviewing the Instructions for NEET Exam will give you a clearer picture of the exam structure and marking scheme.
Hard Biomolecules NEET Questions (10-15 Questions)
These high-difficulty questions test deep conceptual understanding, reaction mechanisms, numerical-based questions, and tricky application-based concepts that are commonly asked in NEET Chemistry and Biology.
1-5: Advanced Carbohydrate & Lipid Questions
- The glycosidic bond in sucrose is formed between:
- (a) C1 of glucose and C4 of fructose
- (b) C1 of glucose and C2 of fructose
- (c) C2 of glucose and C1 of fructose
- (d) C1 of glucose and C6 of fructose
- Answer: (b) C1 of glucose and C2 of fructose
- Which of the following lipids is not amphipathic?
- (a) Phospholipids
- (b) Cholesterol
- (c) Triacylglycerol
- (d) Glycolipids
- Answer: (c) Triacylglycerol
- What happens when a protein is denatured?
- (a) Its primary structure is disrupted
- (b) Its secondary and tertiary structures are disrupted
- (c) Both primary and secondary structures are disrupted
- (d) The number of amino acids changes
- Answer: (b) Its secondary and tertiary structures are disrupted
- The iodine test for carbohydrates gives a blue-black color with:
- (a) Glucose
- (b) Starch
- (c) Sucrose
- (d) Fructose
- Answer: (b) Starch
- Which of the following molecules cannot pass through a phospholipid bilayer by simple diffusion?
- (a) Oxygen
- (b) Carbon dioxide
- (c) Water
- (d) Glucose
- Answer: (d) Glucose
6-10: Nucleic Acids & Enzyme Kinetics
- The Chargaff’s rule states that in DNA:
- (a) A + T = G + C
- (b) A = G and T = C
- (c) A + G = T + C
- (d) A = T and G = C
- Answer: (d) A = T and G = C
- The Km (Michaelis constant) of an enzyme represents:
- (a) Maximum reaction rate
- (b) Half of the substrate concentration required for Vmax
- (c) The total enzyme concentration
- (d) The enzyme inhibition rate
- Answer: (b) Half of the substrate concentration required for Vmax
- If an enzyme has low Km, it means:
- (a) It has high affinity for the substrate
- (b) It has low affinity for the substrate
- (c) It requires more substrate to reach Vmax
- (d) It works only at high substrate concentrations
- Answer: (a) It has high affinity for the substrate
- The function of telomerase in DNA replication is to:
- (a) Remove RNA primers
- (b) Prevent chromosome shortening
- (c) Unwind the DNA helix
- (d) Ligate Okazaki fragments
- Answer: (b) Prevent chromosome shortening
- The most unstable RNA that is degraded quickly is:
- (a) tRNA
- (b) mRNA
- (c) rRNA
- (d) snRNA
- Answer: (b) mRNA
11-15: Numerical & Tricky Biomolecule Questions
- If 1 mole of glucose undergoes complete oxidation, the total ATP produced is:
- (a) 24 ATP
- (b) 38 ATP
- (c) 12 ATP
- (d) 48 ATP
- Answer: (b) 38 ATP
- Which amino acid is NOT optically active?
- (a) Glycine
- (b) Alanine
- (c) Serine
- (d) Tyrosine
- Answer: (a) Glycine
- The molecular weight of glucose is 180 g/mol. If a solution contains 90 g of glucose in 1 L of water, what is its molarity?
- (a) 1 M
- (b) 0.5 M
- (c) 2 M
- (d) 0.25 M
- Answer: (b) 0.5 M
- Solution: Molarity = (Mass / Molar Mass) × Volume = (90/180) × 1 = 0.5 M
- The number of peptide bonds in a tripeptide is:
- (a) 1
- (b) 2
- (c) 3
- (d) 4
- Answer: (b) 2
- Which vitamin is essential for the synthesis of coenzyme A?
- (a) Vitamin B2
- (b) Vitamin B5
- (c) Vitamin B6
- (d) Vitamin C
- Answer: (b) Vitamin B5
Many aspirants often ask: “Am I eligible to give NEET again?” or “Is there an age limit for NEET?” If you’re unsure, take a moment to go through the NEET Maximum Age Limit to avoid any last-minute surprises.
Tips & Tricks to Solve Biomolecules NEET Questions Quickly
Biomolecules is a high-scoring yet tricky topic in NEET Chemistry & Biology. Follow these smart strategies to solve Biomolecules MCQs quickly and accurately in the exam.
- Memorize Important Functional Groups & Bonds
- Know glycosidic bonds (carbohydrates), peptide bonds (proteins), ester bonds (lipids), and phosphodiester bonds (nucleic acids).
- Understand the α and β forms of glucose and how they link to form disaccharides like maltose, lactose, and sucrose.
- Master the ATP Calculation in Biomolecules Metabolism
- Glucose oxidation → 38 ATP (aerobic) | 2 ATP (anaerobic glycolysis)
- Learn Krebs cycle intermediates and enzyme co-factors (NADH, FADH₂).
- Understand Enzyme Kinetics & Inhibition
- Km ↓ = High substrate affinity (enzyme works better at low substrate concentration).
- Competitive inhibitors increase Km but don’t change Vmax.
- Mnemonics for Biomolecule Classification
- Amino Acids: “PVT TIM HALL” → Essential Amino Acids.
- Purines & Pyrimidines: “Pure As Gold” (Purines: Adenine, Guanine), “CUT the Py” (Pyrimidines: Cytosine, Uracil, Thymine).
- Solve Previous Year NEET Questions & Mock Tests
- 85% of NEET Biomolecules questions are PYQ-based! Solve at least 10 years of previous papers.
- Take timed mock tests to improve speed & accuracy.
Final Tip: Revise daily with flashcards & quick notes, and you’ll master Biomolecules for NEET 2025!
Conclusion: Master Biomolecules for NEET 2025 Success!
Biomolecules is a high-yielding topic in NEET Chemistry & Biology, with direct, conceptual, and numerical-based questions appearing every year. By mastering carbohydrates, proteins, lipids, nucleic acids, enzyme kinetics, and ATP production, you can easily secure full marks in this section.
- Key Takeaways:
- Memorize biomolecule structures, bonds, and functions.
- Practice numerical questions on ATP yield, enzyme kinetics, and molecular weights.
- Solve previous years’ NEET questions to identify repeating patterns.
- Take mock tests to improve speed and accuracy.
With NEET being a competitive exam, every mark counts. Stay consistent, practice daily, and make sure you also go through topics like Animal Kingdom NEET Questions to strengthen your Biology preparation.
